Complex (pleiotropic) Tax functions:
|
Tax function (induction/ repression) |
Origin of Tax (HTLV-1/2/3/4, BLV) |
Experimental evidence |
Mechanism, comments, reference (facultative) |
|
|
Results |
Methods/Animal model |
|||
|
Leukemia (induction) |
Tax1 |
Leukemia of NK-like lymphocytes |
Transgenic mouse Transgene with granzyme B promoter |
Grossman et al., 1995, Lairmore et al., 2005 |
|
Apoptosis (repression) |
Tax1 |
resistance to apoptosis |
Stimulation with FAS-Ligand |
Activation of anti apoptotic genes |
|
Nucleotide excision repair (NER), (repression) |
Tax1 |
|
|
Stimulation of PCNA (Marriott and Semmes, 2005) |
|
Aneuploidy (induction) |
Tax1 |
|
Karyotype analysis |
|
|
Micronuclei (induction) |
Tax1 |
|
|
|
|
Spindle assembly checkpoint (repression) |
Tax1 |
|
|
Binding to MAD1(Jin et al, 1998) |
|
T-cell immortalization (induction) |
Tax1 |
human CD4 T-cell, IL-2 dependent |
Transduction of human cord blood lymphocytes by a retrovirus vector |
(Akagi et al., 1993) |
|
T-cell immortalization (induction) |
Tax1 |
human CD4 T-cell IL-2 dependent |
Transduction of human cord blood lymphocytes by a rhadinovirus vector |
Stimulation of G1-S phase (Grassmann et al .,1992) |